Quantified Reference Extracts are issued from the research work of the Institut des Substances Végétales (ISV), a private French research institute established since 1979.

ISV was founded by Daniel Jean, PhD, former assistant professor of Pharmacognosy at the University of Clermont-Ferrand, France.

ISV’s research focuses: production processes of herbal products, ethnobotany, pharmacology of plant compounds and development of analytical methods dedicated to herbal product characterization.

In the last 39 years, ISV was granted over 30 patents in Europe, North America, Africa and Japan.
 Some of ISV’s innovations have been licensed and successfully commercialized by major French and other international companies in herbal medicine, cosmetics, dietary supplements and pharmaceuticals.

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Among ISV’s main innovations:

  • SIPF, Suspensions Intégrales de Plantes Fraîches (1981): first type of herbal medicinal products to be designed in the spirit of phytotherapy, they were initially manufactured by Vaillant-Defresnes lab and are still on the French market. This type of product has become a reference, described in phytotherapy’s training manuals.
  • Ethnodex (1984): the first cosmetic product against cutaneous melanic hyperpigmentation without hydroquinone.
  • Antiviral procyanidines from Cupressus sempervirens (1989), commercialized by a French laboratory since 2000.
  • The Phytostandards or EPS (2000) the latest evolution of phytotherapy products, commercialized by a French laboratory since 2000. EPS has become today’s reference for phytotherapeutic prescribed products in France.
  • A product against bedsores (2001).
  • Molecules extracted from Rosmarinus officinalis proven to be active in protein deglycation (2010). Patent pending.
  • Development of a topical medical device used in the treatment of atopic dermatitis. Commercialized in Europe by Elatium (2010).
  • AGE Breaker (2011), a rosemary extract commercialized in Europe, Russia, Africa and Asia as a dietary supplement to fight aging.
  • Nitric oxide scavengers for treatment of skin inflammation (2015).
  • Development of a line of more than 300 Traditional Chinese Mecicine herbal extracts, commercialized in Switzerland by compounding pharmacies (2016).